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Techniques evolved in the post -omics era have given us opportunity to accelerate discovery process by looking at
many cellular processes simultaneously. Advances in computational power, algorithms, and modern database mining techniques
are accelerating the discovery science even more. New powerful techniques to study large number of genes and proteins
at a time are getting more and more sophisticated. New strategies are emerging to identify the role of specific genes
in causing and counteracting diseases.
We have successfully established a laboratory where we can integrate molecular biology, genomics, proteomics, QSAR and protein
modelling to identify pathways, regulatory proteins, putative drug targets and small molecule agonist/antagonist using modern
techniques. Presently we are engaged in the following work.
Chemical genetics approach is used to understand the biological functions of a protein without mutating the protein. This
approach can identify small molecules that would be valuable in deciphering function of homologous proteins in a wide variety
of organisms. We are using in-silico techniques for searching novel inhibitors of yeast, leishmania and
mycobacterium sirtuins.
In last century achievements of recombinant DNA technology has revolutionised modern biology and accomplish significant dynamic
growth of biotech industries. The basis of this new technology is the ability to introduce genetic material from virtually
any source in to cells to alter the genetic makeup of the cell and produce desired products. We are currently engaged in cloning
of a two commercially important gene phytase from A. niger and oxido-reductase from G. candidum .
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